Spreading lung cancer cells are like tents which have collapsed and are adrift in the wind, scientists from the University of York have discovered.
Communication between two proteins is what triggers the cell tent to lose its shape and become unanchored, their research found.
This allows the cells to travel to other areas of the body.
The researchers said their findings could help prevent the spread of lung cancer.
Writing in the Journal of Clinical Investigation, researchers from York and the University of Texas describe how the communications centre of a cell – known as the Golgi apparatus – receives a signal from proteins which prompts the movement of membrane sacks inside it.
This movement alters the shape and surface of the cancer cell, allowing it to break free from its moorings and move around freely.
Dr Daniel Ungar, from the University of York’s biology department, said it was apt to think of the cancer cell resembling a tent structure.
“It has fixed sides to hold its shape and is firmly anchored to the ground in order to secure its contents.
“In order to move the tent, we have to rearrange its contents and collapse its sides in order to lift it out of its anchored position and carry it away,” he said.
He added that a similar process happens with cancer when it spreads – its outer edges are altered leaving it unanchored.
The study found that a protein called Zeb1 was critical to this process and the research team now want to look at how to target the protein without damaging healthy cells, in which the protein also exists.
The researchers only looked at lung cancer cells and do not know if the same process occurs in other cancers.
Zimbawe’s doctor goes missing after masterminding strike
Fearless Zimbabwe’s minister of health has called on the government to address insecurity lapses that has lead to the disappearance Peter Magombeyi, the head of a doctor’s union, who disappeared on Saturday.
Fears are rising over the fate of Zimbabwe medical doctor Dr Peter Magombeyi after he sent a message to say he had been abducted in that country by unknown persons – apparently for demanding a “living wage”.
An AFP report earlier on Sunday quoted the Zimbabwe Hospital Doctor’s Association (ZHDA) as saying Magombeyi had not been heard from since he sent a WhatsApp message on Saturday night saying he had been “kidnapped by three men”.
Zimbabwe doctors, who earn a miserly equivalent of about R3 000 are on strike to press for better wages, equipment and medicines in state hospitals.
The ZHDA has reportedly accused state security forces of abducting the doctor because of his role in organising work stoppages.
This week some doctors said the death of deposed Robert Mugabe, 95, in a Singapore hospital on 6 September was an indication of how bad health services in Zimbabwe
“Dr Magombeyi’s crime is only to ask for a living wage for his profession. This is a reflection of the troubles born out of refusal to implement Political Reforms.”
The Zimbabwe government led by Emmerson Mnangagwa has not publicly commented on the doctor’s disappearance
Turkey: Group calls for immediate action against Femicide
Emine Dirican, a beautician from Istanbul, tried to be a good wife. But her husband hated that she worked, that she socialized, even that she wanted to leave the house sometimes without him.
She tried to reason with him. He lashed out.
“One time, he tied me — my hands, my legs from the back, like you do to animals,” recalls Dirican, shuddering. “He beat me with a belt and said, ‘You’re going to listen to me, you’re going to obey whatever I say to you.’ “
She left him and moved in with her parents. In January, he showed up, full of remorse and insisting he had changed. She let him in.
In her mother’s kitchen, he grabbed her by the hair, threw her to the floor and pulled out a gun.
“He shot me,” she says. “Then he went back to my mom and he pulled the trigger again, but the gun was stuck. So he hit her head with the back of the gun.”
Her father, who was in another room in the house, heard the gunshots and ran over. Dirican almost bled to death after a bullet ripped through a main artery in one of her legs.
“I was telling my father, ‘Daddy, please, I don’t want to die.’ “
Femicide — killing women because of their gender — is a longstanding issue in Turkey. Nearly 300 women have been killed so far this year, according to the Istanbul-based advocacy group We Will Stop Femicide, which has been tracking gender-related deaths since Turkish authorities stopped doing so in 2009.
Source Npr news